Endocrine Abstracts

Introduction: It has been previously described that prolactinomas may have a more aggressive behaviour in men than in women.Methods: We performed a retrospective study in 59 patients diagnosed of prolactinoma (19 men). The variables collected were: age at diagnosis, clinical presentation, tumor size and stage (Hardy classification) and treatment response. The results were compared between both genders.Results: Age at diagnosis was ...

Exposure to high levels of glucocorticoids (GCs) at critical stages in development is thought to compromise immune function in adulthood (1), but the underlying mechanisms are poorly understood. Accordingly, we have examined the effects of perinatal dexamethasone treatment on the expression in the adult thymus of (a) inducible nitric oxide synthase (NOS-2, paradoxically also expressed constitutively in the thymus) which liberates NO, a factor involved in the negative selection...

Enhanced corticosterone release by female compared to male rats under basal and stress conditions has been frequently evidenced (1). The demonstration that gonadectomy enhances stress-induced corticosterone secretion in male rats (2) but reduces such levels in female rats (3) suggests a causal association between gonadal steroids and corticosterone release. The present study examined the corticosterone profile of intact and gonadectomised female and male rats under basal and s...

Glucocorticoid remediable aldosteronism (GRA) was first described in 1966 by Sutherland et ala. In this family, aldosterone secretion was regulated by ACTH and symptoms and signs were reversed by the administration of exogenous glucocorticoid. GRA is usually characterised by moderate to severe hypertension with early onset. The hypertension is often difficult to control and is associated with greatly increased vascular risk. It is inherited as an autosomal dominant trait and ...

Introduction: The increased risk of cancer in patients with diabetes mellitus (DM) creates an interest in finding mechanisms of the possible association of antidiabetic drugs and carcinogenesis. Metformin has the most documented evidence of pleiotropic oncoprotective effects, including increased stabilization of tumour suppressor p53, inhibition of NF-κB activation, slowing of the cell cycle and inhibition of mitosis due to decreased expression of cyclin D and cyclin E, a...

Objectives: The Clinical Activity Score (CAS) is used to measure and classify Graves orbitopathy activity (GO). However, CAS is partly subjective, and the evaluation of its components is binary. As CAS is known to be correlated with TSH receptor antibodies (TRAb), we wanted to evaluate other immunological parameters in the peripheral blood as markers of GO activity.Methods: The study included 32 patients (19 females, 13 males). CAS was evaluated by a sin...

Introduction: Severe insulinopenic diabetes (SID) is a rare complication of treatment with immune checkpoint inhibitors (ICPI). We describe herein the clinical characteristics, natural history and potential predictors of SID in cancer patients treated with ICPI.Methods: We identified and retrospectively retrieved pertinent clinical data of all patients who presented with new onset SID following treatment with ICPI between 2015 and 2022 at the Tel Aviv-So...

Introduction: Increased levels of high-sensitivity C-reactive protein (hs-CRP) and interleukin 6 (IL-6) accelerates atherosclerosis and occurrence of cardiovascular complications in patients with type 2 diabetes (T2D). Intima-media thickness (IMT) is a surrogate marker of atherosclerosis in patients with T2D.Aim: The aim of the study was to evaluate the significance of determining inflammatory markers IL-6, hs-CRP and IMT, as atherosclerosis markers, dur...

Transient neonatal diabetes mellitus (TNDM) occurs in 50-60% of all cases of neonatal diabetes mellitus (NDM). The most common cause of TNDM (70%) is almost invariably associated with defect in chromosome 6 and mutations in the KCNJ11, ABCC8, INS, NHF1B etc. genes. TNDM is caused by mutations in the GATA6 gene in rare cases. This gene encodes a transcription factor that is important for the development of the hematopoietic, cardiac and gastrointestinal systems.<p ...

We identified factors that significantly influenced the development of the X-syndrome. A significant influence on the development of X-syndrome have increase the level of total cholesterol (b=0.65; P=0.036; Exp (b) =1.92 (1.04÷3.54)). Increases the risk of X-syndrome increase the level of apo-B-protein (b=4.79; P=0.014; Exp (b) =12.69 (2.68÷54.41)). The increase in linear dimension of preperitonialy fat increased ...